Structure of PDB 8tcg Chain A

Receptor sequence
>8tcgA (length=440) Species: 9606 (Homo sapiens) [Search protein sequence]
FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGI
VEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRS
KQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDAD
GQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVY
SIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTL
GMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLF
MDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDL
DQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSG
CPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARP
3D structure
PDB8tcg De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D284 N286 D288 Y290 D292 D284 N286 D288 Y290 D292
BS02 CA A D349 D351 D353 F355 D357 D349 D351 D353 F355 D357
BS03 CA A D414 D416 N418 Y420 D422 D414 D416 N418 Y420 D422
BS04 CA A D230 N232 D234 I236 D238 D230 N232 D234 I236 D238
Gene Ontology
Cellular Component
GO:0008305 integrin complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8tcg, PDBe:8tcg, PDBj:8tcg
PDBsum8tcg
PubMed37704610
UniProtP06756|ITAV_HUMAN Integrin alpha-V (Gene Name=ITGAV)

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