Structure of PDB 8tcf Chain A

Receptor sequence
>8tcfA (length=444) Species: 9606 (Homo sapiens) [Search protein sequence]
FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGI
VEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRS
KQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDAD
GQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVY
SIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTL
GMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLF
MDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDL
DQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSG
CPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITV
3D structure
PDB8tcf De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D284 N286 D288 Y290 D292 D284 N286 D288 Y290 D292
BS02 CA A D349 D351 D353 F355 D357 D349 D351 D353 F355 D357
BS03 CA A D414 D416 N418 Y420 D422 D414 D416 N418 Y420 D422
BS04 CA A N232 D234 I236 D238 N232 D234 I236 D238
Gene Ontology
Cellular Component
GO:0008305 integrin complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8tcf, PDBe:8tcf, PDBj:8tcf
PDBsum8tcf
PubMed37704610
UniProtP06756|ITAV_HUMAN Integrin alpha-V (Gene Name=ITGAV)

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