Structure of PDB 8tc5 Chain A

Receptor sequence
>8tc5A (length=1087) Species: 231513 (Civet SARS CoV SZ3/2003) [Search protein sequence]
LDRCTTFDDVQAPNYTQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSN
VTGFHTINHTFDNPVIPFKDGIYFAATEKSNVVRGWVFGSTMNNKSQSVI
IINNSTNVVIRACNFELCDNPFFAVSKPMGTQTHTMIFDNAFNCTFEYIS
DAFSLDVSEKSGNFKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNT
LKPIFKLPLGIKITNFRAILTAFLPAQDTWGTSAAAYFVGYLKPTKFMLK
YDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVR
FPNITNLCPFGEVFNATKFPSVYAWERKRISNCVADYSVLYNSTSFSTFK
CYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDD
FMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGK
PCTPPALNCYWPLKDYGFYTTSGIGYQPYRVVVLSFELLNAPATVCGPKL
STDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDP
KTSEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDAWRIYSTGNN
VFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTVQKSIVAYTMSLGAD
SSIAYSNNTIAIPTNFLISITTEVMPVSMAKTSVDCNMYICGDSTECANL
LLQYGSFCAQLNRALSGIAVEQDRNTREVFAQVKQMYKTPTLKDFGGFNF
SQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICA
QKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQM
AYRFNGIGVAQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVV
NQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQ
SLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSF
PQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSW
FITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYD
3D structure
PDB8tc5 Cryo-EM reveals variation in structural motifs within animal SARS-related coronavirus spike proteins
ChainA
Resolution2.11 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EIC A Y339 F366 Y337 F364
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8tc5, PDBe:8tc5, PDBj:8tc5
PDBsum8tc5
PubMed38805567
UniProtP59594|SPIKE_SARS Spike glycoprotein (Gene Name=S)

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