Structure of PDB 8tbu Chain A

Receptor sequence
>8tbuA (length=509) Species: 9606 (Homo sapiens) [Search protein sequence]
QQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEM
IKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDT
KGPEIRTGEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGG
RIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLS
EQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIE
NHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGK
PVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPV
EAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFK
CCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPL
LYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYT
NIMRVLSIS
3D structure
PDB8tbu Structure-Based Design of AG-946, a Pyruvate Kinase Activator.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I0R A F69 Q436 L437 F12 Q371 L372
BS02 PYR A K313 E315 A336 G338 D339 K248 E250 A271 G273 D274
BS03 FBP A L474 T475 T476 T477 S480 R532 G557 R559 G561 S562 Y564 T565 L409 T410 T411 T412 S415 R467 G492 R494 G496 S497 Y499 T500
BS04 MN A E315 D339 E250 D274
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
Biological Process
GO:0001666 response to hypoxia
GO:0006096 glycolytic process
GO:0007584 response to nutrient
GO:0009749 response to glucose
GO:0010038 response to metal ion
GO:0016310 phosphorylation
GO:0032869 cellular response to insulin stimulus
GO:0033198 response to ATP
GO:0042866 pyruvate biosynthetic process
GO:0051591 response to cAMP
GO:0071872 cellular response to epinephrine stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tbu, PDBe:8tbu, PDBj:8tbu
PDBsum8tbu
PubMed38109501
UniProtP30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)

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