Structure of PDB 8tbr Chain A

Receptor sequence

>8tbrA (length=163) Species: 362242 (Mycobacterium ulcerans Agy99) [Search protein sequence]

SVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVMGRRTWDSL
PAAHRPLPGRRNVVVTRQTGLVAHGAQVVGSLEQALSPAEPDAATWVIGG
AQIYALALPLANRCEVTEVDVDLPPEDEDALAPVLDQTWAGTSGEWLVSR
SGLRYRMHSYRRL

3D structure

PDB

8tbr Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM758

Chain

Resolution

1.75 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	W8 A9 I16 G17 G21 I22 G45 R46 R47 T48 V67 T68 R69 I100 G102 A103 Q104 I105	W6 A7 I14 G15 G19 I20 G43 R44 R45 T46 V65 T66 R67 I98 G100 A101 Q102 I103
BS02	HIJ	A	I7 W8 I22 D29 F33 K34 L52 P53 H56 L59 R62 I100	I5 W6 I20 D27 F31 K32 L50 P51 H54 L57 R60 I98

External links

PDB	RCSB:8tbr, PDBe:8tbr, PDBj:8tbr
PDBsum	8tbr
PubMed
UniProt	A0PQG8

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