Structure of PDB 8tbi Chain A

Receptor sequence
>8tbiA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQ
IKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTR
QGVEDAFYTLVREIRQYR
3D structure
PDB8tbi Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
ChainA
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G13 G15 K16 S17 A18 F28 V29 D30 P34 T35 G60 N116 K117 D119 S145 A146 K147 G14 G16 K17 S18 A19 F29 V30 D31 P35 T36 G61 N117 K118 D120 S146 A147 K148
BS02 MG A S17 T35 S18 T36
BS03 ZNI A P34 T35 I36 A59 Q61 Y64 M67 P35 T36 I37 A60 Q62 Y65 M68
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0000165 MAPK cascade
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0045445 myoblast differentiation
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:8tbi, PDBe:8tbi, PDBj:8tbi
PDBsum8tbi
PubMed38589574
UniProtP01111|RASN_HUMAN GTPase NRas (Gene Name=NRAS)

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