Structure of PDB 8tb6 Chain A

Receptor sequence
>8tb6A (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
RTLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRLRVVLKVLDPSHHD
IALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLR
RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEG
TSPFIKLSDPGVGLGALSREERVERIPWLAPECLPSTAMDKWGFGATLLE
ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR
PSFRTILRDLTRL
3D structure
PDB8tb6 Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712.
ChainA
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOI A Q597 G598 V603 V640 K642 T687 E688 Y689 V690 P694 R738 N739 L741 Q24 G25 V30 V40 K42 T87 E88 Y89 V90 P94 R138 N139 L141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8tb6, PDBe:8tb6, PDBj:8tb6
PDBsum8tb6
PubMed37823891
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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