Structure of PDB 8tah Chain A

Receptor sequence
>8tahA (length=403) Species: 9913 (Bos taurus) [Search protein sequence]
GRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKEKGVDDLDFFIGDE
AIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEP
PLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG
TVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGI
PPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKK
EFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPL
YKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDV
QVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFG
VMS
3D structure
PDB8tah Mechanism of Synergistic Activation of Arp2/3 Complex by Cortactin and WASP-Family Proteins
ChainA
Resolution2.89 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R230 Y231 Y233 P236 K251 W252 K254 R329 D330 R333 R334 R215 Y216 Y218 P221 K236 W237 K239 R314 D315 R318 R319
BS02 ATP A G13 Y16 G171 D172 K228 E229 G324 M327 R374 G11 Y14 G156 D157 K213 E214 G309 M312 R359
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0030030 cell projection organization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060271 cilium assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0035861 site of double-strand break
GO:0042995 cell projection

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8tah, PDBe:8tah, PDBj:8tah
PDBsum8tah
PubMed37898612
UniProtP61157|ARP3_BOVIN Actin-related protein 3 (Gene Name=ACTR3)

[Back to BioLiP]