Structure of PDB 8tad Chain A

Receptor sequence
>8tadA (length=253) Species: 3988 (Ricinus communis) [Search protein sequence]
KQYPIINFTTAGATVQSYTNFIRAVRGRLTTGVRHEIPVLPNRVGLPINQ
RFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAIT
HLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYS
TGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVI
TLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALM
VYR
3D structure
PDB8tad Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
ChainA
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZXJ A Y183 L232 R234 R235 F240 Y178 L227 R229 R230 F235
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:8tad, PDBe:8tad, PDBj:8tad
PDBsum8tad
PubMed38340640
UniProtP02879|RICI_RICCO Ricin

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