Structure of PDB 8t98 Chain A

Receptor sequence
>8t98A (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
QTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEE
EPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDW
EDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFET
3D structure
PDB8t98 Biochemical and Structural Characterization of a Giant Virus Inositol Pyrophosphate Kinase
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.10: endopolyphosphatase.
3.6.1.52: diphosphoinositol-polyphosphate diphosphatase.
3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming).
3.6.1.62: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U6J A R10 K18 R20 S39 S40 R41 I47 G50 G51 G52 E66 E70 R89 R115 K133 R3 K11 R13 S32 S33 R34 I40 G43 G44 G45 E59 E63 R82 R108 K126
BS02 MG A G50 E70 G43 E63
BS03 MG A E66 E70 E59 E63
Gene Ontology
Molecular Function
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8t98, PDBe:8t98, PDBj:8t98
PDBsum8t98
PubMed38216735
UniProtO95989|NUDT3_HUMAN Diphosphoinositol polyphosphate phosphohydrolase 1 (Gene Name=NUDT3)

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