Structure of PDB 8t8s Chain A

Receptor sequence

>8t8sA (length=636) Species: 9606 (Homo sapiens) [Search protein sequence]

CGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLV
IMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLT
AEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALST
ENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALE
LWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGD
TWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIV
YSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGG
RWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAV
GIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIV
AIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISI
WGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCI
LGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPESK
CVEQPLKGHDLEFCLYLTTNGYRKIPGDKCQGGVNP

3D structure

PDB

8t8s Structural studies of Sortilin-PGRN peptide complex

Chain

Resolution

2.99 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	L75 S78 V79 S80 L81 K227 F273 G274 L275 S283 R292 Y318 S319 I320 L321 Y362 T537 G538 W553 W564	L23 S26 V27 S28 L29 K175 F221 G222 L223 S231 R240 Y266 S267 I268 L269 Y310 T485 G486 W501 W512

External links

PDB	RCSB:8t8s, PDBe:8t8s, PDBj:8t8s
PDBsum	8t8s
PubMed
UniProt	Q99523\|SORT_HUMAN Sortilin (Gene Name=SORT1)

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