Structure of PDB 8t8n Chain A

Receptor sequence
>8t8nA (length=320) Species: 11036 (Venezuelan equine encephalitis virus) [Search protein sequence]
DVFQNKANVCWAKALVPVLKTAGIDMTTEQWNTVDYFETDKAHSAEIVLN
QLCVRFFGLDLDSGLFSAPTVPLSIRNNHWDNSPSPNMYGLNKEVVRQLS
RRYPQLPRAVATGRVYDMNTGTLRNYDPRINLVPVNRRLPHALVLHHNEH
PQSDFSSFVSKLKGRTVLVVGEKLSVPGKMVDWLSDRPEATFRARLDLGI
PGDVPKYDIIFVNVRTPYKYHHYQQCEDHAIKLSMLTKKACLHLNPGGTC
VSIGYGYADRASESIIGAIARQFKFSRVCKPKSSLEETEVLFVFIGYDRK
ARTHNPYKLSSTLTNIYTGS
3D structure
PDB8t8n In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.
ChainA
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 074 A K473 A474 N475 V476 C477 K480 A509 H510 I542 N545 H546 W547 K6 A7 N8 V9 C10 K13 A42 H43 I75 N78 H79 W80
External links
PDB RCSB:8t8n, PDBe:8t8n, PDBj:8t8n
PDBsum8t8n
PubMed37515189
UniProtP27282|POLN_EEVVT Polyprotein P1234

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