Structure of PDB 8t7o Chain A

Receptor sequence

>8t7oA (length=407) Species: 9606 (Homo sapiens) [Search protein sequence]

KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDAT
NDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNI
LGGTVFREAIICKNIPRLVSGWVKPIIIGHHYRATDFVVPGPGKVEITYT
PSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPL
YLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQ
AMKSEGGFIWACKNGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAH
GTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANAL
EEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKL
AQAKLLE

3D structure

PDB

8t7o Mechanistic and Biostructural Studies of Mutant IDH1

Chain

Resolution

2.053 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	T75 I76 T77 R82 N96 L288 H309 G310 T311 V312 R314 H315 T327 N328	T73 I74 T75 R80 N94 L279 H300 G301 T302 V303 R305 H306 T318 N319
BS02	IV3	A	L120 M259 V276 Q277 S280 V281	L118 M252 V267 Q268 S271 V272

External links

PDB	RCSB:8t7o, PDBe:8t7o, PDBj:8t7o
PDBsum	8t7o
PubMed
UniProt	O75874\|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Gene Name=IDH1)

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