Structure of PDB 8t7d Chain A

Receptor sequence
>8t7dA (length=395) Species: 9606 (Homo sapiens) [Search protein sequence]
KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDAT
NDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNI
LGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYATDFVVPGPGKVEITYT
PSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPL
YLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQ
AMKSEGGFIWACKNYYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMY
QKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEA
GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
3D structure
PDB8t7d Mechanistic and Biostructural Studies of Mutant IDH1
ChainA
Resolution3.444 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZT3 A R109 A111 I113 R119 W124 I130 M291 R107 A109 I111 R117 W122 I128 M272
External links
PDB RCSB:8t7d, PDBe:8t7d, PDBj:8t7d
PDBsum8t7d
PubMed
UniProtO75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Gene Name=IDH1)

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