Structure of PDB 8t7c Chain A

Receptor sequence

>8t7cA (length=1001) Species: 9606 (Homo sapiens)

QIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLD
IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSK
EDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLREL
KTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKS
ILDEFGSGSAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRET
AEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTY
LTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKI
KFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLL
TKPTEASADQLPSPSQLREKIIIKHKKLGPHKQQGELYMWDSIDQKWTRH
YCAIADAKLSFSDDIEPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLI
RKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYE
KHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQ
RTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPS
NYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKS
FVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKQSIAIELSDLVV
YCKPTSKTNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYP
KGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYV
LQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEV
EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVY
EEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMR
P

3D structure

• PDB: 8t7c The crystal and cryo-EM structures of PLCg2 reveal dynamic inter-domain recognitions in autoinhibition
• Chain: A
• Resolution: 2.55 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	N328 E357 D359 E406	N298 E327 D329 E376

External links

• PDB: RCSB:8t7c, PDBe:8t7c, PDBj:8t7c
• PDBsum: 8t7c
• UniProt: P16885|PLCG2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Gene Name=PLCG2)