Structure of PDB 8t70 Chain A

Receptor sequence
>8t70A (length=318) Species: 5207 (Cryptococcus neoformans) [Search protein sequence]
TYIPMSQRRSWADVKPIMQDDGPNPVVPIMYSEEYKDAMDYFRAIAAKEE
KSERALELTEIIVRMNPAHYTVWQYRFSLLTSLNKSLEDELRLMNEFAVQ
NLKSYQVWHHRLLLLDRISPQDPVSEIEYIHGSLLPDPKNYHTWAYLHWL
YSHFSTLGRISEAQWGSELDWCNEMLRVDGRNNSAWGWRWYLRVSRPGAE
TSSRSLQDELIYILKSIHLIPHNVSAWNYLRGFLKHFSLPLVPILPAILP
YTAFGFPMPSDPLPEDTPLPVPLALEYLADSFIEQNRVDDAAKVFEKLSS
EYDQMRAGYWEFRRRECA
3D structure
PDB8t70 Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
ChainA
Resolution1.892 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.58: protein farnesyltransferase.
2.5.1.59: protein geranylgeranyltransferase type I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y74 Y109 Q110 Y70 Y105 Q106
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0004660 protein farnesyltransferase activity
GO:0004662 CAAX-protein geranylgeranyltransferase activity
GO:0008318 protein prenyltransferase activity
Biological Process
GO:0018342 protein prenylation
GO:0018343 protein farnesylation
GO:0018344 protein geranylgeranylation
Cellular Component
GO:0005737 cytoplasm
GO:0005953 CAAX-protein geranylgeranyltransferase complex
GO:0005965 protein farnesyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t70, PDBe:8t70, PDBj:8t70
PDBsum8t70
PubMed
UniProtJ9VSJ6

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