Structure of PDB 8t5s Chain A

Receptor sequence
>8t5sA (length=693) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
QLCLRNYQEELCQVALQGKNTIVTAPTGSGKTVIAANIIKEHFESRSSEG
KRFKALFMTPNSMILNQQAASISSYLDHVYHTQIIQGSDNVPTRNVIQSK
DLIVATPQMIVNLCNEHRNSLDSRLDQFFLSTFTIIFFDECHNTVKNSPY
SNIMREYHYLKNMGNMPEGHSLPQIIGLTASLGTGDKNDCLQVRNYIAGL
CASMDVKDLSIVKDNLEELRGYSPIVPDKVLLCERSTDGPIGMFTNRLTL
MMQEVEGLIRTALRNEHIGSFLDPPADKEHAGYQNWVCNQMNLVSGTSFR
ETGTRTIINEALDVLKECFCTLSYNINFHPEVALNYLKDEMEYRTPNFTV
NMIRIWERYHNQLVGTGSAENPMISKTVQYIVEQNLQRADSRTIIFVRTR
YEATILNKVLNSNEELLMLGIKSEWMSGLNKSTASSADISASKQKQMEKL
KMFADGEIRILVSTSVAEEGLDVPECSLVIKYNYATNEIAHVQRRGRGRA
LNSECVLITNSIALRDQESNNRDKESLMSETISLIQNSPAEFRKCVDEES
NKIWPRILREDTDKAQKIEEQINRNIVYKIICKKCEAILCTSKDIRSRNT
QYLVCDPGFWSLVRKTRTGSINCRRENCGLKLGQLIEVNTVDLPCLSALS
IVLLVEGTDKRIIVKKWKNILDKYFTPTEIRQLDVQTMRDADQ
3D structure
PDB8t5s C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t5s, PDBe:8t5s, PDBj:8t5s
PDBsum8t5s
PubMed38747717
UniProtG5EDI8

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