Structure of PDB 8t5n Chain A

Receptor sequence
>8t5nA (length=398) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVELKENIKRQWWRS
VVTGRDDVVGIDSSIILPREVWVASGHVDVFHDPREFNMMLKTYLGPIET
EEGLHYLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNF
IFRTREFEQMEMEFFVEPATAKEWHQYWIDNRLQWYIDLGIRRENLRLWE
HPKDKLSHYSDRTVDIEYKFGFMGNPWGELEGVANRTDFDLSTHARHSGV
DLSFYDQINDVRYTPYVIEPAAGLTRSFMAFLIDAYTEDKRTVLRLDPRL
APVKAAVLPLSRHADLSPKARDLGAELRKCWNIDFDDAGAIGRRYRRQDE
VGTPFCVTVDFDSLQDNAVTVRERDAMTQDRVAMSSVADYLAVRLKGS
3D structure
PDB8t5n Crystal Structure of Glycine--tRNA ligase from Mycobacterium tuberculosis (AMP-Mg bound)
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.14: glycine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A K29 S30 K27 S28
BS02 AMP A R195 E197 F205 R206 T207 F210 Q212 E282 L283 A324 G326 R329 R142 E144 F152 R153 T154 F157 Q159 E229 L230 A271 G273 R276
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004820 glycine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006426 glycyl-tRNA aminoacylation
GO:0015966 diadenosine tetraphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle
GO:1990742 microvesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t5n, PDBe:8t5n, PDBj:8t5n
PDBsum8t5n
PubMed
UniProtP9WFV7|SYG_MYCTU Glycine--tRNA ligase (Gene Name=glyQS)

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