Structure of PDB 8t5m Chain A

Receptor sequence
>8t5mA (length=463) Species: 9606 (Homo sapiens) [Search protein sequence]
LRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYH
MYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDASADLKRFR
KEYVQPVQLRILNVFRHWVEHHFYDFERDLYLLERLESFISSVRGKAMKK
WVESIAKIIRRKKQAQANITFESPPPPIEWHISKPGHIETFDLMTLHPIE
IARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL
WFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSV
YRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIY
LTNILKTEEGNNDFLTRHGKDLINFSKRRKVAEITGEIQQYQNQPYCLRI
EPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNPKQPPRFPRKSTF
SLKSPGIRPNTGR
3D structure
PDB8t5m Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 YIF A Y882 D885 F888 R896 D900 Y301 D304 F307 R315 D319
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function

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Biological Process
External links
PDB RCSB:8t5m, PDBe:8t5m, PDBj:8t5m
PDBsum8t5m
PubMed38156904
UniProtQ07890|SOS2_HUMAN Son of sevenless homolog 2 (Gene Name=SOS2)

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