Structure of PDB 8t5g Chain A

Receptor sequence
>8t5gA (length=461) Species: 9606 (Homo sapiens) [Search protein sequence]
LRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYH
MYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADLKRFRKE
YVQPVQLRILNVFRHWVEHHFYDFERDLYLLERLESFISSVRGKAMKKWV
ESIAKIIRRKKQAQANITFESPPPPIEWHISKPGHIETFDLMTLHPIEIA
RQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF
EKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYR
LDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLT
NILKTEEGNNDFLTRHGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEP
DMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNPKQPPRFPRKSTFSL
KSPGIRPNTGR
3D structure
PDB8t5g Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
ChainA
Resolution1.92 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 THA A N877 Y882 F888 E889 R896 N294 Y299 F305 E306 R313
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8t5g, PDBe:8t5g, PDBj:8t5g
PDBsum8t5g
PubMed38156904
UniProtQ07890|SOS2_HUMAN Son of sevenless homolog 2 (Gene Name=SOS2)

[Back to BioLiP]