Structure of PDB 8t4v Chain A

Receptor sequence
>8t4vA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKEK
3D structure
PDB8t4v Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 D30 N116 K117 D119 L120 S145 A146 K147 G14 V15 G16 K17 S18 A19 D31 N117 K118 D120 L121 S146 A147 K148
BS02 Y63 A V9 D12 A59 G60 E62 Y64 R68 D69 M72 H95 Y96 Q99 R102 V103 V10 D13 A60 G61 E63 Y65 R69 D70 M73 H96 Y97 Q100 R103 V104
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8t4v, PDBe:8t4v, PDBj:8t4v
PDBsum8t4v
PubMed38443470
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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