Structure of PDB 8t4h Chain A

Receptor sequence
>8t4hA (length=533) Species: 9606 (Homo sapiens) [Search protein sequence]
SETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLM
SILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRDTSTLSDSLSE
NLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQL
LEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN
QKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQ
MQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDGLLTPLHLEGLVQFQDVS
FAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTG
GQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTM
EEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIR
KPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQA
DHILFLEGGAIREGGTHQQLMEKKGCYWAMVQA
3D structure
PDB8t4h Transporter associated with antigen processing (TAP) bound to the 8-mer peptide RRYQSTEL
ChainA
Resolution3.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E242 D246 E301 S304 L305 Y309 Y408 V460 E61 D65 E100 S103 L104 Y108 Y207 V259
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015433 ABC-type peptide antigen transporter activity
GO:0023029 MHC class Ib protein binding
GO:0042288 MHC class I protein binding
GO:0042605 peptide antigen binding
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0046978 TAP1 binding
GO:0046979 TAP2 binding
GO:1904680 peptide transmembrane transporter activity
Biological Process
GO:0002250 adaptive immune response
GO:0006952 defense response
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0046967 cytosol to endoplasmic reticulum transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0034451 centriolar satellite
GO:0042824 MHC class I peptide loading complex
GO:0042825 TAP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t4h, PDBe:8t4h, PDBj:8t4h
PDBsum8t4h
PubMed
UniProtQ03518|TAP1_HUMAN Antigen peptide transporter 1 (Gene Name=TAP1)

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