Structure of PDB 8t41 Chain A

Receptor sequence

>8t41A (length=859) Species: 1773 (Mycobacterium tuberculosis)

ALPNLTRDQAVERAALITVDSYQIILDVTDGNGAPGERTFRSTTTVVFDA
LPGADTVIDISAHTVRRASLNDQDLDVSGYDEAAGIPLRGLAQRNVVVVD
ADCHYSNTGEGLHRFVDPVDGETYLYSQFETADAKRMFACFDQPDLKATF
DVRVTAPAHWKVISNGAPLAAANGVHTFATTPRMSTYLVALIAGPYAAWT
DTYIDDHGEIPLGIYCRASLAEYMDAERLFTQTKQGFGFYHKHFGLPYAF
GKYDQLFVPEFNAGAMENAGAVTFLEDYVFRSKVTRASYERRAETVLHEM
AHMWFGDLVTMTWWDDLWLNESFATFASVLCQSEATEFTEAWTTFATVEK
SWAYRQDQLPSTHPIAADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGL
ERFLAGLRDYFRTHAFGNASFDDLLAALEKASGRDLSNWGEQWLKTTGLN
TLRPDFEVDAEGRFTRFAVTQSGAAPGAGETRVHRLAVGIYDDDGSKSSG
KLVRVHREELDVSGPITNVPALVGVSRGKLILVNDDDLTYCSLRLDERSL
QTALDRIADIAEPLPRTLVWSAAWEMTREAELRARDFVSLVSGGVHAETE
VGVAQRLLLQAQTALGCYAEPGWARERGWPQFADRLLELAREAEPGSDHQ
LAYINSLCSSVLSPRHVQTLGALLEGEPAACGLAGLAVDTDLRWRIVTAL
ATAGAIDADGPETPRIDAEVQRDPTAAGKRHAAQARAARPQFVVKDEAFT
TVVEDDTLANATGRAMIAGIAAPGQGELLKPFARRYFQAIPGVWARRSSE
VAQSVVIGLYPHWDISEQGITAAEEFLSDPEVPPALRRLVLEGQAAVQRS
LRARNFDAD

3D structure

• PDB: 8t41 Crystal structure of aminopeptidase N from Mycobacterium tuberculosis
• Chain: A
• Resolution: 1.45 Å

Enzymatic activity

• Enzyme Commision number: 3.4.11.2: membrane alanyl aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H299 H303 E322	H298 H302 E321
BS02	MG	A	E131 E801	E130 E800

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0042277 peptide binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0043171 peptide catabolic process

Cellular Component

• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0016020 membrane

External links

• PDB: RCSB:8t41, PDBe:8t41, PDBj:8t41
• PDBsum: 8t41
• UniProt: L7N655