Structure of PDB 8t3r Chain A

Receptor sequence
>8t3rA (length=450) Species: 9606 (Homo sapiens) [Search protein sequence]
QVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFAL
LGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVL
VVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTY
NYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRR
VIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPL
GLRSEFPIWMMFASALPALLVFILIFLESQITHLDLLLVVGMGGVAALFG
MPWLSATTVRSVTHANKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFG
IFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQ
IICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADD
3D structure
PDB8t3r Cryo-EM structure of the band 3 anion transport protein
ChainA
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PIO A P815 K817 Y818 P375 K377 Y378
BS02 PIO A P598 G599 R603 P195 G196 R200
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0008509 monoatomic anion transmembrane transporter activity
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015297 antiporter activity
GO:0030492 hemoglobin binding
GO:0030506 ankyrin binding
GO:0042803 protein homodimerization activity
GO:0043495 protein-membrane adaptor activity
GO:0140900 chloride:bicarbonate antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006820 monoatomic anion transport
GO:0006821 chloride transport
GO:0006873 intracellular monoatomic ion homeostasis
GO:0007596 blood coagulation
GO:0015701 bicarbonate transport
GO:0017121 plasma membrane phospholipid scrambling
GO:0035811 negative regulation of urine volume
GO:0045852 pH elevation
GO:0048821 erythrocyte development
GO:0051453 regulation of intracellular pH
GO:0055085 transmembrane transport
GO:0072659 protein localization to plasma membrane
GO:0098660 inorganic ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate
Cellular Component
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030018 Z disc
GO:0030863 cortical cytoskeleton
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0170014 ankyrin-1 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t3r, PDBe:8t3r, PDBj:8t3r
PDBsum8t3r
PubMed
UniProtP02730|B3AT_HUMAN Band 3 anion transport protein (Gene Name=SLC4A1)

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