Structure of PDB 8t2u Chain A

Receptor sequence
>8t2uA (length=448) Species: 9606 (Homo sapiens) [Search protein sequence]
PVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVF
LCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVI
VACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRI
YVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIF
SSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYV
VGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRH
DLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYG
RFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPS
QVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQP
3D structure
PDB8t2u Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y189 Y190 L192 S225 F231 Y185 Y186 L188 S221 F227
BS02 CA A D245 D247 T250 E252 D241 D243 T246 E248
BS03 CA A D365 D367 D369 Y371 D373 D361 D363 D365 Y367 D369
BS04 CA A D426 D428 N430 Y432 D434 D422 D424 N426 Y428 D430
BS05 CA A D297 N299 D301 R303 D305 D293 N295 D297 R299 D301
Gene Ontology
Molecular Function
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0050840 extracellular matrix binding
GO:0060090 molecular adaptor activity
GO:0070051 fibrinogen binding
Biological Process
GO:0001525 angiogenesis
GO:0002687 positive regulation of leukocyte migration
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0033627 cell adhesion mediated by integrin
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031092 platelet alpha granule membrane
GO:0070062 extracellular exosome
GO:0070442 integrin alphaIIb-beta3 complex
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t2u, PDBe:8t2u, PDBj:8t2u
PDBsum8t2u
PubMed37443315
UniProtP08514|ITA2B_HUMAN Integrin alpha-IIb (Gene Name=ITGA2B)

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