Structure of PDB 8t1r Chain A

Receptor sequence
>8t1rA (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]
LVPRGSIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGL
EGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTH
ATKAIYRWLLSDYVKVDMLYTETDLEESMDKIETINFHEVKEVAGIKFWC
YHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILII
ESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLIL
DEYWQNHPELHDIPIYYASSVFKHISNLKSMDHFDDIGPSVVMASPGMMQ
SGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLP
LKMSVDYISFSAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIR
EYEDNDEVHIEVHNPRNTEAVTLNFR
3D structure
PDB8t1r Anticancer benzoxaboroles inhibit pre-mRNA processing by direct inhibition of CPSF3
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XZC A P45 H73 L74 D75 H76 Y110 H158 D179 F241 Q333 V359 H396 H418 P48 H76 L77 D78 H79 Y113 H155 D176 F238 Q300 V326 H363 H385
BS02 FE A D75 H76 D179 H418 D78 H79 D176 H385
BS03 FE A H71 H73 H76 H158 D179 H74 H76 H79 H155 D176
External links
PDB RCSB:8t1r, PDBe:8t1r, PDBj:8t1r
PDBsum8t1r
PubMed37967558
UniProtQ9UKF6|CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 (Gene Name=CPSF3)

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