Structure of PDB 8t1q Chain A

Receptor sequence
>8t1qA (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
LVPRGSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPG
LEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMT
HATKAIYRWLLSDYVKVMLYTETDLEESMDKIETINFHEVKEVAGIKFWC
YHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILII
ESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLIL
DEYWQNHPELHDIPIYYASSAVYQTYFVFKHISNLKSMDHFDDIGPSVVM
ASPGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITT
MSGQKLPLKMSVDYISFSAHTDYQQTSEFIRALKPPHVILVHGEQNEMAR
LKAALIREYEDNDEVHIEVHNPRNTEAVTLNFR
3D structure
PDB8t1q Anticancer benzoxaboroles inhibit pre-mRNA processing by direct inhibition of CPSF3
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XYX A I43 P45 H73 L74 D75 H76 Y110 H158 D179 F241 Q333 S334 H396 H418 I47 P49 H77 L78 D79 H80 Y114 H155 D176 F238 Q307 S308 H370 H392
BS02 FE A D75 H76 D179 H418 D79 H80 D176 H392
BS03 FE A H71 H73 H158 D179 H75 H77 H155 D176
External links
PDB RCSB:8t1q, PDBe:8t1q, PDBj:8t1q
PDBsum8t1q
PubMed37967558
UniProtQ9UKF6|CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 (Gene Name=CPSF3)

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