Structure of PDB 8t0z Chain A

Receptor sequence
>8t0zA (length=409) Species: 9606 (Homo sapiens) [Search protein sequence]
LSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRV
VQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIF
EDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQ
SCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNALSLNEEGIPHNPMVN
AGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETG
DRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLA
NGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVS
GAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRH
CARKLDPRR
3D structure
PDB8t0z Filament formation drives catalysis by glutaminase enzymes important in cancer progression.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN A Q218 S219 Y251 N268 E314 N321 Y347 V417 Q150 S151 Y183 N200 E246 N253 Y279 V349
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006537 glutamate biosynthetic process
GO:0006541 glutamine metabolic process
GO:0006543 glutamine catabolic process
GO:0042981 regulation of apoptotic process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Cellular Component
External links
PDB RCSB:8t0z, PDBe:8t0z, PDBj:8t0z
PDBsum8t0z
PubMed38438397
UniProtQ9UI32|GLSL_HUMAN Glutaminase liver isoform, mitochondrial (Gene Name=GLS2)

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