Structure of PDB 8szs Chain A

Receptor sequence
>8szsA (length=856) Species: 9685 (Felis catus) [Search protein sequence]
TVEPYKVNLSQDLEHQLQNVIQELNLEIVPPPEDPFLPVVLNLGKSQRQI
GVVPWSPPQSNWNPWTSSNIDEGPLAYATPEQISMDLKNELMYQLEQDHD
LQAILQERELLPVKKFESEILEAISQNSVIIIRGATGCGKTTQVPQFILD
DFIQNDRAAECNIVVTQPRRISAVSVAERVAYERGEEPGKSCGYSVRFES
VLPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVVL
RDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLED
CIQMTHFVPPANCNLICGDEYGPETRMSMAQLNEKETPFELIEALLKYIE
TLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPREEQ
RKVFDPVPSGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHNNM
TNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFR
TPLHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDAN
DELTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAVCTISAATCFPEPFIS
EGKRLGYVHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRL
NMATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLL
AFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVF
GEKIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIRLQISHE
AAACITALRAAMEALVVEVTKQPNIISQLDPVNEHMLNMIRQISRPSAAG
INLMID
3D structure
PDB8szs Development of Assays to Support Identification and Characterization of Modulators of DExH-Box Helicase DHX9.
ChainA
Resolution2.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A T414 G415 G417 K418 T419 T420 R457 F700 T722 N724 T136 G137 G139 K140 T141 T142 R179 F404 T426 N428
BS02 MG A T419 E513 T141 E235
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0033679 3'-5' DNA/RNA helicase activity

View graph for
Molecular Function
External links
PDB RCSB:8szs, PDBe:8szs, PDBj:8szs
PDBsum8szs
PubMed37625785
UniProtM3WPI7

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