Structure of PDB 8szp Chain A

Receptor sequence
>8szpA (length=855) Species: 9606 (Homo sapiens) [Search protein sequence]
EPYKVNLSQDLEHQLQNIIQELNLEILPPPEDPSVPVALNIGKPSQRQNQ
VGVVPWSPPQSNWNPWTSSNIDEGPLAFATPEQISMDLKNELMYQLEQDH
DLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFIL
DDFIQNDRAAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFE
SILPRPHASIMFCTVGVLLRKLEAGIRGISHVIVDEIHERDINTDFLLVV
LRDVVQAYPEVRIVLMSATIDTSMFCEYFFNCPIIEVYGRTYPVQEYFLE
DCIQMTHFVPPPDANCNLICGDEYGPETRLSMSQLNEKETPFELIEALLK
YIETLNVPGAVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQILPLHSQIPR
EEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAN
YATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTP
LHEIALSIKLLRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDE
LTPLGRILAKLPIEPRFGKMMIMGCIFYVGDAICTIAAATCFPEPFINEG
KRLGYIHRNFAGNRFSDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNM
ATLRMTWEAKVQLKEILINSGFPEDCLLTQVFTNTGPDNNLDVVISLLAF
GVYPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYPSPFFVFGE
KIRTRAISAKGMTLVTPLQLLLFASKKVQSDGQIVLVDDWIKLQISHEAA
ACITGLRAAMEALVVEVTKQPAIISQLDPVNERMLNMIRQISRPSAAGIN
LMIDY
3D structure
PDB8szp Crystal structures of DExH-box RNA helicase DHX9
ChainA
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T413 G414 G416 K417 T418 T419 R456 F699 T721 N723 T137 G138 G140 K141 T142 T143 R180 F407 T429 N431
BS02 MG A T418 E512 T142 E236
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0033679 3'-5' DNA/RNA helicase activity

View graph for
Molecular Function
External links
PDB RCSB:8szp, PDBe:8szp, PDBj:8szp
PDBsum8szp
PubMed37860960
UniProtQ08211|DHX9_HUMAN ATP-dependent RNA helicase A (Gene Name=DHX9)

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