Structure of PDB 8szg Chain A

Receptor sequence

>8szgA (length=830) Species: 9606 (Homo sapiens)

YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKS
FLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEE
RDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKE
IVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFRE
FLKKVHPRKSVHNGFAKEFWEETFNCHLQEFRPLCTGDENISSVETPYID
YTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQV
LKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGY
YNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPT
CCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTE
PFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKI
PTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEI
IFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFS
MLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYII
LFKPSRNTIEEVRCSTAAHAFKVAARATLR

3D structure

• PDB: 8szg Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor
• Chain: A
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YP4	A	F684 I777 F814 W818 Y825	F624 I717 F754 W758 Y765
BS02	CA	A	N82 S84 L88	N63 S65 L69
BS03	TRP	A	T145 S147 A168 Y218	T113 S115 A136 Y186

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8szg, PDBe:8szg, PDBj:8szg
• PDBsum: 8szg
• PubMed: 38326620
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)