Structure of PDB 8szf Chain A

Receptor sequence

>8szfA (length=799) Species: 9606 (Homo sapiens)

YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
IDSLHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ
FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREE
AEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPL
IKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPG
FREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEFRPLCTGDENISSVETP
YIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEA
WQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKE
VGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEG
EPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLS
WTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFS
LLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLNLQF
LLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGF
LIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAY
ASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRC

3D structure

• PDB: 8szf Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor
• Chain: A
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TRP	A	T145 S147 A168 S170 Y218 E297	T116 S118 A139 S141 Y189 E268
BS02	CA	A	S84 L87 L88	S65 L68 L69
BS03	YP4	A	Q681 F684 I777 T780 W818 Y825	Q624 F627 I702 T705 W743 Y750

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8szf, PDBe:8szf, PDBj:8szf
• PDBsum: 8szf
• PubMed: 38326620
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)