Structure of PDB 8sya Chain A

Receptor sequence
>8syaA (length=359) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence]
MWVKILSVVGARPQFIKAAAVSRVLRASPGVREVLVHTGQHYDDNMSQVF
FEELEIPDPDYHLGIGGGTHGQNTGRMLEAIEGVLLKEKPDWVLVYGNTD
STLAGALAAVKLHIPVAHVEAGLRSFNRRMPEEINRILTDHASDLLFAPT
ETAVQNLLREGIPENRIHLVGDVMYDAALHYGAKAERKSRILERLGLQAK
GYVLATIHRAENTDDQERLRVILEALAEVHQEVPVVFPVHPRTRKRAEAF
GLGSYLEKVVALEPVGYLDMVMLEKNARLIVTDSGGVQKEAYFYRVPCVT
VREETEWVELLKAEWNYLAAPQNAKDLALTILHRMRTKGVEIDLYGDGRA
SQKISDFLR
3D structure
PDB8sya Structural analysis of a bacterial UDP-sugar 2-epimerase reveals the active site architecture before and after catalysis.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.1.3.14: UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing).
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 MJL A R12 P13 Q14 I16 K17 F50 G97 N98 E120 E132 R136 H208 R209 V265 Y267 M270 S284 G285 E290 W307 R12 P13 Q14 I16 K17 F50 G97 N98 E120 E132 R136 H208 R209 V265 Y267 M270 S284 G285 E290 W307
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity
GO:0016853 isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:8sya, PDBe:8sya, PDBj:8sya
PDBsum8sya
PubMed37660908
UniProtQ72KY0

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