Structure of PDB 8sxu Chain A

Receptor sequence
>8sxuA (length=726) Species: 9606 (Homo sapiens) [Search protein sequence]
NLLLNDYWVHNEMKAEIKMFFETNENKDTTYQNLWDAFKAVCRGKFIALN
AYKRKQEIKNDKGDITTDPTEIQTTIREYYKHLYANKLENLEEMDTFLDT
YTLPRLNQEEVESLNRPITGSEIVAIINSLPTKKSPGPDGFTAEFYQRYK
EELVPFLLKLFQSIEKEGILPNSFYEASIILIPKPGRDTTKKENFRPISL
MNIDAKILNKILANRIQQHIKKLIHHDQVGFIPGMQGWFNIRKSINVIQH
INRAKDKNHVIISIDAEKAFDKIQQPFMLKTLNKLGIDGMYLKIIRAIYD
KPTANIILNGQKLEAFPLKTGTRQGCPLSPLLFNIVLEVLARAIRQEKEI
KGIQLGKEEVKLSLFADDMIVYLENPIVSAQNLLKLISNFSKVSGYKINV
QKSQAFLYNNNRQTESQIMGELPFTIASKRIKYLGIQLTRDVKDLFKENY
KPLLKEIKEDTNKWKNIPCSWVGRINIVKMAILPKVIYRFNAIPIKLPMT
FFTELEKTTLKFIWNQKRARIAKSILSQKNKAGGITLPDFKLYYKATVTK
TAWYWYQNRDIDQWNRTEPSEIMPHIYNYLIFDKPEKNKQWGKDSLLNKW
CWENWLAICRKLKLDPFLTPYTKINSRWIKDLNVKPKTIKTLEENLGITI
QDIGVGKDFMSKTPKAMATKDKIDKWDLIKLKSFCTAKETTIRVNRQPTT
WEKIFATYSSDKGLISRIYNELKQIY
3D structure
PDB8sxu Structures, functions, and adaptations of the human LINE-1 ORF2 protein.
ChainA
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A K469 S470 I517 I533 K541 F566 P568 Q571 G660 P662 Y878 I1050 S1051 K134 S135 I182 I198 K206 F231 P233 Q236 G325 P327 Y543 I715 S716
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003964 RNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006310 DNA recombination
GO:0032197 retrotransposition
GO:0090304 nucleic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8sxu, PDBe:8sxu, PDBj:8sxu
PDBsum8sxu
PubMed38096902
UniProtO00370|LORF2_HUMAN LINE-1 retrotransposable element ORF2 protein

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