Structure of PDB 8sx2 Chain A

Receptor sequence
>8sx2A (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
SEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISL
NDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLG
LLAKKADLCQLIRDMVNVCENPPSLAKYRALRCKIEHVEQNTEEFLRVRK
EVLQNHHSKSPVDVLQIFRVGRVNETTEFLSKLGNVRPLLHGSPVQNIVG
ILCRGLLLPKVVEVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDV
ALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQ
VKMKYIIKFSMPG
3D structure
PDB8sx2 Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UHB A H438 G439 S440 N444 G447 I448 G452 L454 P456 Y477 Y488 H191 G192 S193 N197 G200 I201 G205 L207 P209 Y222 Y233
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8sx2, PDBe:8sx2, PDBj:8sx2
PDBsum8sx2
PubMed37971310
UniProtQ9UKK3|PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 (Gene Name=PARP4)

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