Structure of PDB 8swy Chain A

Receptor sequence
>8swyA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
SEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLGSPNPPSLA
KYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRVNET
TEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLG
SGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEA
PPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSMPGDQI
3D structure
PDB8swy Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A H438 G439 S440 N444 G447 I448 G452 L453 L454 G470 N471 Y477 F478 Y488 E547 H115 G116 S117 N121 G124 I125 G129 L130 L131 G147 N148 Y154 F155 Y165 E224
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8swy, PDBe:8swy, PDBj:8swy
PDBsum8swy
PubMed37971310
UniProtQ9UKK3|PARP4_HUMAN Protein mono-ADP-ribosyltransferase PARP4 (Gene Name=PARP4)

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