Structure of PDB 8swn Chain A

Receptor sequence

>8swnA (length=1135) Species: 9913 (Bos taurus)

VLPEDRSQHLGEELQGYWDQEVLRAEKDAREPSLTKAIIKCYWKSYVVLG
IFTLIEESTRVVQPIILGKIIGYFENYDPSDSAALYEAHGYAGVLSACTL
VLAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVN
LLSNDVNKFDQVTIFLHFLWAGPLQAIVVTALLWMEIGISCLAGMAVLII
LLPLQSCIGKLFSSLRSKTAAFTDTRIRTMNEVITGIRIIKMYAWEKSFA
DLITNLRRKEISKILRSSYLRGMNLASFFVASKIIVFVTFTTYVFLGNVI
TASRVFVAVSLYGAVRLTVTLFFPSAVEKVSEAFVSIRRIKNFLLLDEIM
IVNVQDFTAFWDKASDTPTLQSLSFTVRPGELLAVVGPVGAGKSSLLSAV
LGELPPNQGQVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVI
KACALKKDLQLLEDGDLTMIGDRGTTLSGGQKARVNLARAVYQDADIYLL
DDPLSAVDAEVSRHLFELCICQALHEKIRILVTHQLQYLKAASQILILKD
GQMVQKGVGFKAYKNYFTAGAHWFIIIFLILVNLAAQVSYILQDWWLSYW
ANQQSALNTEKLDLNWYLGIYSGLTASTVLFGIVRSLLVFFVLVSSSQTL
HNQMFESILRAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTYLDFIQTF
LQVIGVVGVAVAVIPWIAIPLVPLGIVFFVLRRYFPVFSHLSSSLQGLWT
IRAYKAEQRFQELFDSHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVV
AFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERV
IEYTDLEKEAPWEYQKRPLPSWPHEGVIIFDNVNFSYSLDGPLVLKHLTA
LIKSKEKVGIVGRTGAGKSSLIAALFRLSEPEGKIWIDKILTTEIGLHDL
RKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWNALEEVQLKEAIEDLP
GKMDTELAESGSNFSVGQRQLVCLARAILRKNRILIIDQATANVDPRTDE
LIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQ
NRDSLFYKMVQQLGKAEAAALTETAKQVYFKRNYP

3D structure

• PDB: 8swn Structural basis of prostaglandin efflux by MRP4.
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	S1082 Q1122	S919 Q959
BS02	MG	A	S452 Q480	S394 Q422
BS03	ATP	A	T534 S536 G537 G538 Y1050 T1077 G1078 G1080 K1081 S1082 S1083 Q1122 H1233	T476 S478 G479 G480 Y887 T914 G915 G917 K918 S919 S920 Q959 H1070
BS04	ATP	A	W419 G448 G450 K451 S452 S453 Q480 S1175 N1176 S1178 G1180	W361 G390 G392 K393 S394 S395 Q422 S1012 N1013 S1015 G1017

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8swn, PDBe:8swn, PDBj:8swn
• PDBsum: 8swn
• PubMed: 38216659
• UniProt: F1MUC1