Structure of PDB 8swa Chain A

Receptor sequence
>8swaA (length=380) Species: 9606 (Homo sapiens) [Search protein sequence]
GVFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMV
LLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSP
DIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMA
DLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITL
EEMRRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRK
IIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVL
VQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVHKNFDLRPGVIVRDLD
LKKPIYQKTACYGHFGRSEFPWEVPRKLVF
3D structure
PDB8swa Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism.
ChainA
Resolution1.999 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.6: methionine adenosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PPK A H29 D31 K181 R264 K265 H14 D16 K166 R249 K250
BS02 SAM A H29 P30 D179 K181 S247 F250 D258 H14 P15 D164 K166 S232 F235 D243
Gene Ontology
Molecular Function
GO:0004478 methionine adenosyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0009087 methionine catabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005829 cytosol
GO:0048269 methionine adenosyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8swa, PDBe:8swa, PDBj:8swa
PDBsum8swa
PubMed37917677
UniProtQ00266|METK1_HUMAN S-adenosylmethionine synthase isoform type-1 (Gene Name=MAT1A)

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