Structure of PDB 8sw5 Chain A

Receptor sequence

>8sw5A (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]

SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLEL
EAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDC
FNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
WSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGY
EFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD

3D structure

PDB

8sw5 A Protein Phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome

Chain

Resolution

2.39 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.3.16: protein-serine/threonine phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Q49 E54 L55 E56 R74 Y78 N86 E116 N117 F119 D166 E167 K168 D242 Y255 F257 R261 E287 L289 M290 C291 F293 Q294 I295 K297 P298 A299	Q44 E49 L50 E51 R69 Y73 N81 E111 N112 F114 D161 E162 K163 D237 Y250 F252 R256 E282 L284 M285 C286 F288 Q289 I290 K292 P293 A294
BS02	MN	A	D92 N124 H173 H248	D87 N119 H168 H243
BS03	MN	A	D64 H66 D92	D59 H61 D87

External links

PDB	RCSB:8sw5, PDBe:8sw5, PDBj:8sw5
PDBsum	8sw5
PubMed
UniProt	P62136\|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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