Structure of PDB 8sw1 Chain A

Receptor sequence
>8sw1A (length=864) Species: 9606 (Homo sapiens) [Search protein sequence]
FERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADI
DIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG
ELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATF
DISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVV
GEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY
PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVV
GHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFV
SADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHD
YIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQ
MGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSE
DPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLES
LLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYT
VWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGH
LDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLT
VLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFAL
SEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISR
LIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKR
DAESIHQYLLQRKA
3D structure
PDB8sw1 Structure of puromycin-sensitive aminopeptidase and polyglutamine binding.
ChainA
Resolution3.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.14: cytosol alanyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E180 A315 A317 E319 E375 D430 E130 A265 A267 E269 E325 D380
BS02 ZN A H352 H356 E375 H302 H306 E325
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
GO:0071456 cellular response to hypoxia
GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sw1, PDBe:8sw1, PDBj:8sw1
PDBsum8sw1
PubMed37440518
UniProtP55786|PSA_HUMAN Puromycin-sensitive aminopeptidase (Gene Name=NPEPPS)

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