Structure of PDB 8svs Chain A

Receptor sequence
>8svsA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLKWSQVRKDLCSLK
VSLQLRGEDGSVWNYKPPADKEIFSLLPHMADMSTYMFKGIISFAKVISY
FRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEQQLL
LEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQF
AITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHP
FATPLMQELFGITSLTERHKILHRLLQE
3D structure
PDB8svs Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
ChainA
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WU2 A L209 V211 L239 L240 M243 S247 A280 F281 Q285 F288 W299 H327 H407 T408 F429 L49 V51 L76 L77 M80 S84 A117 F118 Q122 F125 W136 H158 H238 T239 F260
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8svs, PDBe:8svs, PDBj:8svs
PDBsum8svs
PubMed38744881
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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