Structure of PDB 8svp Chain A

Receptor sequence
>8svpA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGKWSQVRKDLCSLKVS
LQLRGEDGSVWNYKPPADKEIFSLLPHMADMSTYMFKGIISFAKVISYFR
DLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDLLEPM
LKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITL
KSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATP
LMQELFGISLTERHKILHRLLQE
3D structure
PDB8svp Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR
ChainA
Resolution3.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WSX A L209 M243 S247 F251 F281 Q285 F288 W299 H407 L428 L47 M78 S82 F86 F116 Q120 F123 W134 H234 L255
BS02 YGO A L209 M243 S247 F251 F281 Q285 F288 W299 L428 L47 M78 S82 F86 F116 Q120 F123 W134 L255
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8svp, PDBe:8svp, PDBj:8svp
PDBsum8svp
PubMed38744881
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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