Structure of PDB 8su4 Chain A

Receptor sequence
>8su4A (length=340) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]
AVPPSLRLPVIEAAFPRQLHPYWPKLQETTRTWLLEKRLMPADKVEEYAD
GLCYTDLMAGYYLGAPDEVLQAIADYSAWFFVWDDRHDRDIVHGRAGAWR
RLRGLLHTALDSPGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFARHF
HTVIEAYDREFHNRTRGIVPGVEEYLELRRLTSAHWIWTDLLEPSSGCEL
PDAVRKHPAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHH
SLTLEEAIGEVRRRVEECITEFLAVERDALRFADELADGTVRGKELSGAV
RANVGNMRNWFSSVYWFHHESGRYMVDSWDDRSTPPYVNN
3D structure
PDB8su4 Reprogramming the Cyclization Cascade of epi -Isozizaene Synthase to Generate Alternative Terpene Products.
ChainA
Resolution1.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.3.37: epi-isozizaene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N240 S244 E248 N225 S229 E233
BS02 POP A D99 R194 N240 S244 K247 E248 R338 Y339 D84 R179 N225 S229 K232 E233 R323 Y324
BS03 BTM A F95 F96 D99 S198 H333 F80 F81 D84 S183 H318
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0052680 epi-isozizaene synthase activity

View graph for
Molecular Function
External links
PDB RCSB:8su4, PDBe:8su4, PDBj:8su4
PDBsum8su4
PubMed37449555
UniProtQ9K499|CYC1_STRCO Epi-isozizaene synthase (Gene Name=cyc1)

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