Structure of PDB 8sti Chain A

Receptor sequence
>8stiA (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYGAVSQRLYILLPLDCG
VPDNLSMADPNIRFLDKLPQQDRVYSNSIYELLENGQRAGTCVLEYATPL
QTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQ
EPADDSSFSLSQEVLRHLRQEEK
3D structure
PDB8sti Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates.
ChainA
Resolution1.72 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WX8 A L159 S162 Y163 Y167 Y240 S241 P264 L7 S10 Y11 Y15 Y75 S76 P99
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:8sti, PDBe:8sti, PDBj:8sti
PDBsum8sti
PubMed37486969
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

[Back to BioLiP]