Structure of PDB 8sth Chain A

Receptor sequence
>8sthA (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYGAVSQRLYILLPLDCG
VPDNLSMADPNIRFLDKLPQQRVYSNSIYELLENGQRAGTCVLEYATPLQ
TLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQE
PADDSSFSLSQEVLRHLRQEEKE
3D structure
PDB8sth Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates.
ChainA
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WWU A S162 Y163 Y167 Y240 S241 P264 S10 Y11 Y15 Y74 S75 P98
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:8sth, PDBe:8sth, PDBj:8sth
PDBsum8sth
PubMed37486969
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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