Structure of PDB 8stg Chain A

Receptor sequence
>8stgA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE
AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPL
YVIVEYASKGNLREYLRARRPPVPEEQMTFKDLVSCTYQLARGMEYLASQ
KCIHRDLAARNVLVTENNVMKIADFGRLPVKWMAPEALFDRVYTHQSDVW
SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMR
DCWHAVPSQRPTFKQLVEDLDRILTLT
3D structure
PDB8stg RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.
ChainA
Resolution3.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WCJ A L487 E489 C491 F492 A515 E534 M538 I548 V564 E565 Y566 A567 N631 L633 A643 D644 F645 G646 L27 E29 C31 F32 A55 E74 M78 I88 V104 E105 Y106 A107 N161 L163 A173 D174 F175 G176
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8stg, PDBe:8stg, PDBj:8stg
PDBsum8stg
PubMed37270847
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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