Structure of PDB 8ste Chain A

Receptor sequence
>8steA (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
SSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVH
DFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVH
ADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHD
AFDIQYGVVVIRLKEGLKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCK
IRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIA
FEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLN
ELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGN
HQSVL
3D structure
PDB8ste Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
ChainA
Resolution3.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUN A M794 G796 H822 V823 L863 Y903 M35 G37 H63 V64 L104 Y144
Gene Ontology
Molecular Function
GO:0015377 chloride:monoatomic cation symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ste, PDBe:8ste, PDBj:8ste
PDBsum8ste
PubMed36306358
UniProtP55011|S12A2_HUMAN Solute carrier family 12 member 2 (Gene Name=SLC12A2)

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