Structure of PDB 8ssu Chain A

Receptor sequence

>8ssuA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]

RPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRH
IRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQS
GTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKC
RYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTG
EKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVP

3D structure

PDB

8ssu Structures of CTCF-DNA complexes including all 11 zinc fingers.

Chain

Resolution

2.89 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E336 R339 E362 V363 S364 Y392 K395 Y407 K423 S450	E17 R20 E43 V44 S45 Y73 K76 Y88 K104 S131
BS02	dna	A	E336 R339 H340 Y343 Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 T400 K405 F416 T417 Q418 T421 H425 I446 A447 R448 D451 H455 R479	E17 R20 H21 Y24 Y39 E43 K46 R49 H50 S53 R58 Y67 R70 K74 R77 H78 T81 K86 F97 T98 Q99 T102 H106 I127 A128 R129 D132 H136 R160
BS03	ZN	A	C324 H340 H345	C5 H21 H26
BS04	ZN	A	C353 C356 H369 H373	C34 C37 H50 H54
BS05	ZN	A	C381 C384 H397 H401	C62 C65 H78 H82
BS06	ZN	A	C409 C412 H425 H430	C90 C93 H106 H111
BS07	ZN	A	C439 C442 H455 H460	C120 C123 H136 H141
BS08	ZN	A	C469 C472 H485 H489	C150 C153 H166 H170
BS09	ZN	A	C500 H513 H517	C181 H194 H198
BS10	ZN	A	C525 C528 H541 H546	C206 C209 H222 H227

External links

PDB	RCSB:8ssu, PDBe:8ssu, PDBj:8ssu
PDBsum	8ssu
PubMed	37439339
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF); Q86U70\|LDB1_HUMAN LIM domain-binding protein 1 (Gene Name=LDB1)

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