Structure of PDB 8sss Chain A

Receptor sequence

>8sssA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]

TFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCGRAFRTVTLLRNHLN
THTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVS
KLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHA
RFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHS

3D structure

PDB

8sss Structures of CTCF-DNA complexes including all 11 zinc fingers.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	H322 S334 R342 Y392 K395 Y407 S419 K423 S450	H58 S70 R78 Y128 K131 Y143 S155 K159 S186
BS02	dna	A	Y273 R277 N280 R283 H284 S287 R292 R301 F303 R304 L308 H312 F331 E336 R339 H340 Y343 K344 Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 T400 K405 F416 T417 Q418 T421 H425 K429 R448 D451	Y9 R13 N16 R19 H20 S23 R28 R37 F39 R40 L44 H48 F67 E72 R75 H76 Y79 K80 Y94 E98 K101 R104 H105 S108 R113 Y122 R125 K129 R132 H133 T136 K141 F152 T153 Q154 T157 H161 K165 R184 D187
BS03	ZN	A	C268 C271 H284 H288	C4 C7 H20 H24
BS04	ZN	A	C296 C299 H312 H316	C32 C35 H48 H52
BS05	ZN	A	C324 C327 H340 H345	C60 C63 H76 H81
BS06	ZN	A	C353 C356 H369 H373	C89 C92 H105 H109
BS07	ZN	A	C381 C384 H397 H401	C117 C120 H133 H137
BS08	ZN	A	C409 C412 H425 H430	C145 C148 H161 H166
BS09	ZN	A	C439 C442 H455 H460	C175 C178 H191 H196

External links

PDB	RCSB:8sss, PDBe:8sss, PDBj:8sss
PDBsum	8sss
PubMed	37439339
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)

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