Structure of PDB 8ssr Chain A

Receptor sequence

>8ssrA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]

TRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKR
HIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQ
SGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKK
CRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHT
GEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRN
TMARHADNCA

3D structure

PDB

8ssr Structures of CTCF-DNA complexes including all 11 zinc fingers.

Chain

Resolution

3.14 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	V363 K367 Y392 Y407 K449 S450 K490 Q506 R508 R566 R567 N568 R572	V45 K49 Y74 Y89 K131 S132 K172 Q188 R190 R248 R249 N250 R254
BS02	dna	A	F331 E336 R339 H340 Y343 K344 Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 T400 K405 Q418 H425 K429 R448 H455 K458 R479 Y502 H509 H513 T516 K530 F532 R533 L537 R544 Y545 R566	F13 E18 R21 H22 Y25 K26 Y40 E44 K47 R50 H51 S54 R59 Y68 R71 K75 R78 H79 T82 K87 Q100 H107 K111 R130 H137 K140 R161 Y184 H191 H195 T198 K212 F214 R215 L219 R226 Y227 R248
BS03	ZN	A	C324 H340 H345	C6 H22 H27
BS04	ZN	A	C353 C356 H369 H373	C35 C38 H51 H55
BS05	ZN	A	C381 C384 H397 H401	C63 C66 H79 H83
BS06	ZN	A	C409 C412 H425 H430	C91 C94 H107 H112
BS07	ZN	A	C439 H455 H460	C121 H137 H142
BS08	ZN	A	C472 H485 H489	C154 H167 H171
BS09	ZN	A	C497 C500 H513 H517	C179 C182 H195 H199
BS10	ZN	A	H541 H546	H223 H228
BS11	ZN	A	C557 C560 H573 C577	C239 C242 H255 C259

External links

PDB	RCSB:8ssr, PDBe:8ssr, PDBj:8ssr
PDBsum	8ssr
PubMed	37439339
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)

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